Lumenis IPL Photorejuvenation Results Enhanced With Levulan PDT Combination Treatment

Lumenis^® Ltd. LUME.PK today announced that recently presented clinical study results indicate photorejuvenation skin treatments using the IPL™ Quantum SR system can be enhanced by combining the light treatment with Levulan^® (aminolevulinic acid HCI) Kerastick^®. Lumenis also offers IPL in its Lumenis One^® system.

IPL provides gentle, non-ablative treatments that remove sun-induced freckles, most benign brown pigments, and redness caused by broken capillaries. Lumenis is conducting a series of joint studies with DUSA Pharmaceuticals, Inc. to demonstrate the extent to which IPL treatment results can be enhanced by combining them with Levulan.

Avner Raz, President and Chief Executive Officer, said, “At Lumenis we are absolutely committed to providing the best possible technology and treatments for our customers and their patients. IPL-PDT is an exciting technique and takes photorejuvenation to the next level.”

Dr. Jeffrey S. Dover (Chestnut Hill, MA), lead investigator on the study, stated, “I’ve used the IPL Quantum for several years as a standalone treatment to treat photoaging, and my patients have been very pleased with the great results achieved. By combining Levulan and the Quantum, however, the outcomes are even more impressive. Patients in the study have had a very high degree of satisfaction.”

Clinical Study Results

In results recently presented by Dr. Dover ⁽¹⁾, 20 patients in a prospective, randomized, controlled and split-faced clinical study received a series of treatments for photoaged skin using the IPL Quantum and Levulan. The first three treatments were three weeks apart, in which half of the face was pretreated with Levulan followed in 45 minutes (± 15 minutes) by a full-faced IPL treatment. Each patient then received two additional full-faced, IPL-alone treatments three weeks apart, since the standard of care in non-ablative treatments is five treatments with IPL alone.

Before each treatment and four weeks after the final treatment, patients were assessed by a blinded investigator for global photodamage, fine lines, mottled pigmentation, tactile roughness and sallowness. Combination treatment with Levulan resulted in a statistically significant improvement in global scores for photoaging (80% vs. 50%, p<0.02), and mottled pigmentation (95% vs. 65%, p<0.02). Combination treatment with Levulan also resulted in a significantly greater reduction of mottled pigmentation and fine lines to low or imperceptible levels (p<0.001 and p<0.01, respectively). Investigator evaluations and subject satisfaction scores were both significantly better for the combination treatment sides. The investigators found no difference in the side effect profile with or without combination treatment, and noted that both treatments were well tolerated. No patients dropped out of the study.

⁽¹⁾ Bhatia, AC, Dover, JS, Stewart, B and Arndt, K. Adjunctive use of topical Aminolevulinic acid with Intense Pulsed Light in the Treatment of Photoaging. ASDS 2004.